Status:
COMPLETED
Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine Dependence
Eligibility:
All Genders
18-50 years
Phase:
PHASE2
Brief Summary
We are testing to see if Galantamine, a learning enhancing medication, will help methadone maintained cocaine abusers with their learning and memory specific to CBT using an innovative CBT computer pr...
Detailed Description
We are proposing a randomized double blind clinical trial of galantamine and our innovative computer-assisted version of CBT, alone and in combination, to improve treatment outcome and cognitive funct...
Eligibility Criteria
Inclusion
- Males and females between ages of 18 and 50
- Enrolled in RNP methadone program and stable on methadone for at least 3 weeks
- Current cocaine abuse or dependence according to DSM-IV criteria
- No current medical problems and normal ECG
- If female, not currently pregnant or breast feeding and using reliable birth control
- Fluent in English and have at least a 6th grade reading level
- Can commit to 12 weeks of treatment and are willing to be randomized
Exclusion
- Current major psychiatric illness including mood, psychotic or anxiety disorder
- History of major medical illnesses including asthma, chronic obstructive lung disease, gastrointestinal ulcer, hepatic or renal impairment, cardiac rhythm disturbances
- Use of medications including beta blockers and NASAIDs
- Known allergy to Galantamine
Key Trial Info
Start Date :
December 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00809835
Start Date
December 1 2007
End Date
January 1 2015
Last Update
January 30 2019
Active Locations (2)
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1
Kinsella Treatment Center (KTC)
Bridgeport, Connecticut, United States, 06604
2
Regional Network of Programs
Stratford, Connecticut, United States, 06615