Status:
UNKNOWN
Safety and Effectiveness of Collagen Cross Linking in Progressive Mild and Moderate Keratoconus
Lead Sponsor:
Federal University of São Paulo
Conditions:
Cornea Degeneration
Progressive Keratoconus
Eligibility:
All Genders
15-40 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to evaluate the effectiveness of collagen cross linking (CXL) in reducing progression of mild and moderate progressive keratoconus.
Detailed Description
Keratoconus is a corneal degeneration characterized by bilateral conical protusion and corneal thinning. The course of the disease varies from slight irregular astigmatism to severe visual impairment ...
Eligibility Criteria
Inclusion
- Keratoconus patients, with progression of the disease, based on an increase in the cone apex keratometry of - 0,75 D, alteration of - 0,75 D in the spherical equivalent or increase of the anterior chamber depth on pentacan, in a period of at least six months.
Exclusion
- pregnancy, corneal thickness less than 400 μm, history of corneal surgery, herpes ocular infection, other corneal disease or scarring, chemical injuries and riboflavin allergy
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00815256
Start Date
August 1 2008
Last Update
December 29 2008
Active Locations (1)
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1
Department of Ophthalmology, Federal University of São Paulo
São Paulo, São Paulo, Brazil