Status:
COMPLETED
Plasma Citrulline Concentration in Tropical Enteropathy
Lead Sponsor:
Azienda Ospedaliero-Universitaria di Parma
Conditions:
Malabsorption Syndromes
Granulomatous Enteritis
Eligibility:
All Genders
18-80 years
Brief Summary
Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations. The intestine is thus the only organ t...
Detailed Description
Preliminary studies reported that plasma citrulline concentrations may be a reliable biochemical marker for intestinal dysfunction and absorptive enterocyte mass. The relationship between citrulline c...
Eligibility Criteria
Inclusion
- histologically ascertained Tropical enteropathy
- Mixed HIV status
- Body mass index within normal range
Exclusion
- Patients with surgical resection of stomach, duodenum or pancreas; or (UGI) bypass.
- Patients with other important disease, which may interfere with the study (especially diabetes and renal impairment). Alcoholism, drug abuse or any other circumstances, which may compromise the patient's ability to comply with the study requirements.
- Pregnancy
- Patients experiencing diarrhoea within one month since enrolment date
- Use of glucagon-like peptide 2 (GLP2), growth hormone (GH) or glutamine or triglycerides
- Coeliac Disease, Crohn's disease or infectious intestinal disease
- Patients on steroids or FANS
- Oral feeding\>1.0-fold the estimated basal metabolic rate as assessed using Harris and Benedict equation
Key Trial Info
Start Date :
October 1 1998
Trial Type :
OBSERVATIONAL
End Date :
September 1 2008
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00816842
Start Date
October 1 1998
End Date
September 1 2008
Last Update
January 5 2009
Active Locations (1)
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1
Department of Medicine, University of Zambia School of Medicine, University Teaching Hospital
Lusaka, Lusaka Province, Zambia, P/B RW1X