Status:
COMPLETED
A Trial of Licartin for Preventing Tumor Recurrence After Liver Resection
Lead Sponsor:
Eastern Hepatobiliary Surgery Hospital
Conditions:
Hepatocellular Carcinoma
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
The aim of this study is to analyze the therapeutic effect of adjuvant Licartin therapy after resection.Patients receiving curative resection (R0) were randomized to postoperative Licartin group and n...
Detailed Description
Hepatocellular carcinoma (HCC) represents a major health care challenge in the present era, with its incidence rate of 71128 cases and the mortality rate of 679871 cases during 2007 in the world. Alth...
Eligibility Criteria
Inclusion
- Patients with HCC who received curative liver resection (R0)and with positive expression of HAb18G/CD147 in the HCC tissues
- Karnofsky Performance Score performance over 60
- The functions of the kidney, heart and lung and the blood system are normal and fittable for Licardin therapy.
- The liver function is of grade A or B in Child-Pugh classification.
- Patients give consent to the test.
Exclusion
- Negative expression of HAb18G/CD147 in the HCC tissues
- Allergic history to biologic products(Licartin)
- Any of the situation list below: WBC less than 2000/ml, Hb less than 90g/L or PLT less than 50000/ml, bilirubin level more than 2.5 times the upper limit of normal value, serum albumin less than 32 g/l.
- Severed disease of the heart, lung, kidney, brain and blood system.
- Other severed disease might affect the trial .
- Patients would not sign the consent to the trial.
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00819650
Start Date
December 1 2008
End Date
December 1 2010
Last Update
April 1 2016
Active Locations (1)
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1
Eastern hepatobilliary surgery hospital
Shanghai, Shanghai Municipality, China, 200438