Status:
UNKNOWN
Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
Lead Sponsor:
Barretos Cancer Hospital
Collaborating Sponsors:
University of Sao Paulo
Conditions:
Breast Cancer
Eligibility:
FEMALE
18-70 years
Brief Summary
The purpose of this study is to analyze gene expression signature and immunohistochemical markers associated with clinical and pathological response to neoadjuvant chemotherapy in locally advanced bre...
Detailed Description
Locally advanced breast cancer is a common condition in development countries. Neoadjuvant chemotherapy gives the opportunity to identify genetic signatures associated with objective clinical and path...
Eligibility Criteria
Inclusion
- Women with locally advanced women breast cancer
- Histology: ductal ou lobular invasive histology
- Agreement to take part in the study and signature of the informed consent
- Clinical condition to receive doxorubicin/cyclophosphamide and paclitaxel
- ECOG 0 or I
Exclusion
- Not clinical stage III
- Inflammatory breast cancer
- Previous treatment
- Previous diagnosis of cancer (except basal cell or squamous cell skin carcinoma and non-invasive cervical carcinoma)
- Pregnancy
- Absence of clinical condition to receive chemotherapy
Key Trial Info
Start Date :
July 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2017
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00820690
Start Date
July 1 2008
End Date
September 1 2017
Last Update
August 5 2015
Active Locations (1)
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1
Barretos Cancer Hospital
Barretos, São Paulo, Brazil, 14.784-400