Status:
COMPLETED
Inflammation and the Host Response to Injury (In Healthy Volunteers)
Lead Sponsor:
Rutgers, The State University of New Jersey
Conditions:
Immune System
Eligibility:
All Genders
18-40 years
Phase:
PHASE1
Brief Summary
The body's immune response to injury or infection is very complex.Endotoxin is a man-made substance, which causes the body to "mimic" sickness (fever,chills, and achiness)for a few hours. This study i...
Detailed Description
The body's immune response to injury or infection is very complex.Immune cell activity, the release of specific mediators(such as proteins, genetics(Deoxyribonucleic acid or DNA), the body's "instruct...
Eligibility Criteria
Inclusion
- Good general health as demonstrated by medical history,physical exam, and laboratory tests within 6 weeks of study.
- Written informed consent prior to the performance of any study related procedure.
Exclusion
- History of cancer, rheumatoid arthritis, or immunological, renal, hepatic, endocrine, neurologic, heart disease or hypertension
- Recent history of alcohol or drug abuse
- Mental capacity limited to the extent that the subject cannot provide written informed consent or information regarding treatment-emergent adverse events and/or tolerance of study medication and/or study procedures
- Exposure to any experimental agent or procedure within 30 days of study
- Pregnancy or breast feeding
- Prior exposure to endotoxin in an experimental setting -
Key Trial Info
Start Date :
February 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2011
Estimated Enrollment :
116 Patients enrolled
Trial Details
Trial ID
NCT00820989
Start Date
February 1 2000
End Date
February 1 2011
Last Update
May 21 2014
Active Locations (1)
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1
Rutgers-RWJMS
New Brunswick, New Jersey, United States, 08850