Status:
COMPLETED
Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma
Lead Sponsor:
Papworth Hospital NHS Foundation Trust
Conditions:
Malignant Mesothelioma
Metastatic Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
RATIONALE: Video-assisted surgery to remove part of the tissue layer covering the inside of the chest cavity may be effective in treating pleural effusion and cause less damage to normal tissue. Talc ...
Detailed Description
OBJECTIVES: Primary * Compare the effectiveness of video-assisted thoracoscopic cytoreductive pleurectomy vs talc pleurodesis, in terms of 1-year survival, in patients with suspected or proven malig...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Confirmed or suspected mesothelioma
- Any subtype allowed
- Pleural effusion must be present
- PATIENT CHARACTERISTICS:
- Clinically fit and suitable for video-assisted thoracoscopic cytoreductive pleurectomy
- Prior malignancy allowed provided it no longer requires treatment AND patient has a confirmed diagnosis of mesothelioma
- PRIOR CONCURRENT THERAPY:
- No prior attempted pleurodesis by any approach
Exclusion
Key Trial Info
Start Date :
September 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
196 Patients enrolled
Trial Details
Trial ID
NCT00821860
Start Date
September 1 2003
End Date
May 1 2013
Last Update
June 28 2013
Active Locations (5)
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1
Basildon University Hospital
Basildon, England, United Kingdom, SS16 5NL
2
Papworth Hospital
Cambridge, England, United Kingdom, CB3 8RE
3
Glenfield Hospital
Leicester, England, United Kingdom, LE3 9QP
4
Guy's Hospital
London, England, United Kingdom, SE1 9RT