Status:
COMPLETED
Home-Based Walking Study in Older Adults With Type 2 Diabetes
Lead Sponsor:
University of British Columbia
Conditions:
Cardiovascular
Diabetes
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
Older persons with diabetes have a harder time maintaining blood pressure when standing up. When blood pressure drops when standing up, fainting may occur. This study will see how regular exercise can...
Detailed Description
Detailed Summary 1. PURPOSE: Older adults with diabetes faint frequently, due to an impairment in the cardiovascular control mechanisms (arterial baroreceptor function, autonomic nervous system funct...
Eligibility Criteria
Inclusion
- Type 2 diabetes for at least 5 years treated with diet alone or oral agents
- Nonsmoker for at least 5 years
- Subjects must be sedentary (as defined by no strength training and less than 30 minutes brisk walking/moderate exercise per week and no vigorous exercise in the preceding 6 months)
- All subjects will have a fasting glucose of \<12 mM and a hemoglobin A1c \< 8.5%
- Orthostatic hypotension defined as a decrease in systolic blood pressure of at least 20 mm Hg or diastolic blood pressure of at least 10 mm Hg within 3 minutes of assuming an upright posture on the initial screening visit as per current American Academy of Neurology guidelines.
Exclusion
- Abnormalities on complete blood count, electrolytes or creatinine, on resting ECG, treadmill exercise stress test
- Significant pulmonary, exercise-limiting orthopedic or neurological impairment
- Evidence of valvular disease, exercise-induced syncope, angina, arrhythmias or peripheral vascular disease
- Poor blood pressure control as defined as systolic blood pressure greater than or equal to 160 mm Hg or diastolic blood pressure greater than or equal to 90 mm Hg
- Total cholesterol/HDL cholesterol greater than or equal to 5.0 or LDL cholesterol greater than or equal to 4.21 mmol/L
- Peripheral neuropathy severe enough to cause discomfort (for safety reasons)
- Overt diabetic nephropathy excluding subjects with a urine albumin to creatinine ratio of greater than 2.0 in men or 2.8 in women
- Diabetic retinopathy
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2015
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT00824330
Start Date
January 1 2009
End Date
September 1 2015
Last Update
April 14 2017
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
VITALiTY Research Centre - VGH Research Pavilion
Vancouver, British Columbia, Canada, V5Z 1M9
2
Dr. Scott Lear's Lab, Simon Fraser University, Harbour
Vancouver, British Columbia, Canada, V6B 5K3