Status:
COMPLETED
Brain Effects of Escitalopram and Citalopram Using fMRI
Lead Sponsor:
Michael Henry, MD
Collaborating Sponsors:
Forest Laboratories
Conditions:
Antidepressant Activity in Healthy Volunteers
Eligibility:
MALE
21-50 years
Phase:
PHASE4
Brief Summary
Escitalopram (Lexapro) and citalopram (Celexa) are similar selective serotonin reuptake inhibitors that alter blood flow to the amygdala and other brain structures involved in regulating mood. Escital...
Eligibility Criteria
Inclusion
- Healthy male aged 21 to 50 years.
- Capable of providing informed consent.
- Has an established residence and phone.
Exclusion
- Meets DSM-IV criteria for an Axis I or II disorder.
- History of substance dependence or abuse within the past month.
- Use of NSAID's, beta blockers, calcium channel blockers, antidepressants, antipsychotic medications, lithium or other medication which in the opinion of the investigator would alter vascular responsivity.
- Regular use of sedative hypnotic or narcotic medication, or other medication that might affect the individual's perception of visual stimuli.
- History of cataracts or significant visual impairment.
- A medical condition, which in the opinion of the investigator is likely to affect the individual's perception of the visual stimuli or vascular response.
- Participation in a research protocol that included administration of medication within the past 3 months.
- Cigarette smoking.
Key Trial Info
Start Date :
May 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2011
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT00825825
Start Date
May 1 2007
End Date
April 1 2011
Last Update
July 14 2015
Active Locations (1)
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1
Steward St. Elizabeth's Medical Center
Boston, Massachusetts, United States, 02135