Status:
WITHDRAWN
Anti-inflammatory Effects of Caffeine in Chronic Obstructive Pulmonary Disease (COPD) Subjects
Lead Sponsor:
Maastricht University Medical Center
Collaborating Sponsors:
Technologiestichting STW (NWO)
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
MALE
40-70 years
Phase:
NA
Brief Summary
Nowadays it has become evident that a chronic systemic inflammation is present in patients suffering from chronic obstructive pulmonary disease (COPD). The role of the nuclear enzyme poly(adenosine d...
Eligibility Criteria
Inclusion
- COPD GOLD stage II (50% ≤ FEV1\< 80%)
- CRP plasma levels ≥ 3 mg/l
- BMI \> 20 kg/m2 and \< 30 kg/m2
- Diastolic blood pressure (DBP)=60-90 mmHg, Systolic blood pressure (SBP)=100 150 mmHg
Exclusion
- Physical and/or mental disease or major surgery in the present or the past that might limit participation in or completion of the study
- Reported current or previous metabolic (e.g. diabetes), cardiovascular and/or renal diseases
- Known presence of a carcinoma
- Acute and/or chronic inflammatory condition such as arthritis, arthrosis, chronic colitis, etc. during three months before entry of the study
- Respiratory tract infection or exacerbation of COPD for at least 8 weeks prior to the start of the study
- Change in treatment regime of the COPD subjects for at least 8 weeks prior to the start of the study
- Use of laxatives, anti-diarrhoeal drugs and any other medication that can influence the uptake of the investigational products and/or influence their metabolism during the trial
- During the month prior to the start of the study and during the study the use of antibiotics and/or local and systemic steroidal (glucocorticoids) and non-steroidal anti-inflammatory drugs (NSAID)
- Abnormal constant dietary eating habits and a coffee consumption of less than 3 cups per day (i.e. a usual daily intake of \<400 mg caffeine).
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00826566
Start Date
January 1 2009
End Date
September 1 2009
Last Update
September 23 2015
Active Locations (1)
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1
Maastricht University Medical Centre (UMC+)
Maastricht, Netherlands, 6200 MD