Status:
WITHDRAWN
D-Cycloserine Enhancement of Exposure-Based CBT for Smoking Cessation (DCSSmoking)
Lead Sponsor:
Boston University Charles River Campus
Conditions:
Smokers
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
This study examines whether isolated doses of D-cycloserine enhance the efficacy of CBT for smoking cessation.
Detailed Description
In comparison to placebo-augmented cognitive behavioral therapy (CBT), D-cycloserine-augmented CBT will lead to a greater reduction in both short-and long-term point prevalence abstinence as well as t...
Eligibility Criteria
Inclusion
- 1\. Be a regular smoker for at least one year 3. Currently smoke an average of at least 10 cigarettes per day 4. Report a motivation to quit smoking in the next month of at least 5 on a 10 point scale 5. Score 20 or greater on the 16-item Anxiety Sensitivity Index (Schmidt \& Joiner, 2002).
Exclusion
- Current diagnosis of a psychotic, eating, developmental or bipolar disorder (as determined by the SCID)
- Current anxiety or mood disorder rated moderate or greater (i.e., CGI score of 4 or greater for an anxiety or depressive disorder or any current or recent-1 year--suicidal ideation)
- Psychoactive substance abuse or dependence (excluding nicotine dependence) within the past 6 months
- Current use of isoniazid psychotropic medication
- A history of significant medical condition, such as cardiovascular, neurologic, gastrointestinal, pregnancy and/or breast feeding, history of seizure (other than febrile seizures in childhood) or other systemic illness and/or be deemed as currently unhealthy in the context of a complete physical examination
- Limited mental competency and the inability to give informed, voluntary, written consent to participate,
- Current use of any pharmacotherapy or psychotherapy for smoking cessation not provided by the researchers during the quit attempt,
- Concurrent psychotherapy initiated within three months of baseline, or ongoing psychotherapy of any duration directed specifically toward treatment of anxiety or mood disorder other than general supportive therapy initiated at least 3 months prior to the study
- Use of other tobacco products
- Planning on moving (outside of the immediate area) in the next six months
- Insufficient command of the English language (i.e., they cannot carry on a conversation with an interviewer in the English language or read associated text).
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 15 2015
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00827281
Start Date
August 1 2008
End Date
July 15 2015
Last Update
May 1 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Boston University
Boston, Massachusetts, United States, 02215