Status:
COMPLETED
Effects of Coffee on Hepatic Steatosis Induced by a High Fructose Diet
Lead Sponsor:
University of Lausanne
Collaborating Sponsors:
Nestlé Research Center, Vers-chez-les-blanc, Switzerland
Conditions:
Hepatic Steatosis
Eligibility:
MALE
18-30 years
Phase:
NA
Brief Summary
This study will assess * whether coffee consumption protects against fructose-induced hepatic steatosis in healthy humans * whether the protective effect of coffee is dependent on it's antioxidant co...
Detailed Description
Epidemiological studies suggest that coffee consumption improves glucose homeostasis in insulin resistant subjects. An increase in intrahepatic lipids (hepatic steatosis) is highly prevalent in patien...
Eligibility Criteria
Inclusion
- BMI between 19 and 15 kg/m2
- less than 30 min physical activity /day
- habitual coffee consumption less than three cupy /day
- consumption of caffeine-containing sodas less than 2 servings/day
- non-smoker
Exclusion
- consumption of alcohol more than 40g/day
- presence of metallic foreign bodies
- history of eye surgery
- family history of diabetes mellitus
- history of food intolerance
- vegetarians
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT00827450
Start Date
February 1 2009
End Date
March 1 2011
Last Update
February 24 2012
Active Locations (1)
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1
Centre d'investigations cliniques "cardiomet"/ CHUV
Lausanne, Switzerland, CH-1011