Status:
COMPLETED
Genetic Regulation of Surfactant Deficiency
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Respiratory Distress Syndrome, Newborn
Eligibility:
All Genders
1-6 years
Brief Summary
Inherited deficiencies in any one of 3 genes (surfactant protein B, surfactant protein C, and ATP-binding cassette transporter A3) can cause neonatal respiratory distress syndrome by disrupting metabo...
Detailed Description
Genetic regulation of neonatal pulmonary surfactant deficiency has been suggested by studies of gender, genetic linkage, recurrent familial cases, targeted gene ablation in murine lineages, and by rac...
Eligibility Criteria
Inclusion
- Newborn infants with respiratory distress syndrome who require mechanical ventilation via endotracheal tube or tracheostomy in the first 6 months of life
Exclusion
- Infants with conditions likely to cause imminent death
Key Trial Info
Start Date :
November 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2013
Estimated Enrollment :
525 Patients enrolled
Trial Details
Trial ID
NCT00828243
Start Date
November 1 2007
End Date
March 1 2013
Last Update
June 7 2021
Active Locations (1)
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1
St. Louis Children's Hospital
St Louis, Missouri, United States, 63110