Status:
COMPLETED
The Influence of Intravenous Lidocaine on the Action of the Neuromuscular Blocker Rocuronium
Lead Sponsor:
University Hospital, Geneva
Conditions:
Neuromuscular Block
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
Lidocaine is a local anesthetic which is widely used in daily anesthesia and surgical practice. It has been shown that intravenous lidocaine given during an operation has analgesic properties. Finally...
Eligibility Criteria
Inclusion
- Adult, age ≥18 to 60 years, male or female.
- American Society of Anesthesiology \[ASA\] status I or II.
- Patient is able to read and understand the information sheet and to sign and date the consent form.
- Patient scheduled of elective surgery lasting longer than 120 min without need for continuous curarisation.
- Surgery without application of local anesthetics (epidurals, wound-infiltration).
- If the patient is female and of childbearing potential, she must have a negative pregnancy test.
Exclusion
- A history of allergy or hypersensitivity to rocuronium or lidocaine
- Neuromuscular disease
- Preoperative medications known to influence neuromuscular function (for instance, certain antibiotics \[aminoglycosides\] and anticonvulsants \[phenytoine\])
- Electrolyte abnormalities (for instance, hypermagnesemia)
- Hepatic or renal insufficiency
- Patients with epileptic disease
- Patients with a body mass index \<19 or \>28 kg m2
- Pregnant or breastfeeding women
- Expected difficult intubation or mask ventilation
- Atrioventricular heart block II or III -
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2010
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT00828373
Start Date
August 1 2009
End Date
August 1 2010
Last Update
July 15 2011
Active Locations (1)
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1
University Hospitals of Geneva
Geneva, Switzerland, 1211