Status:
COMPLETED
The Effect of Treatment on Circulating Tumor Cells in Bladder Cancer Patients With Muscle-invasive or Advanced Disease
Lead Sponsor:
University of Colorado, Denver
Conditions:
Bladder Cancer
Eligibility:
All Genders
18+ years
Brief Summary
The investigators hypothesize that circulating tumor cells (CTC) will be observed in patients with muscle-invasive or metastatic bladder cancer and that CTC will become undetectable, at least transien...
Detailed Description
The measurement of circulating tumor cells is pursued in several cancers including breast and prostate cancer. The number of cells measured in these cancers has been shown to be prognostic. There is l...
Eligibility Criteria
Inclusion
- Pathological diagnosis of transitional cell carcinoma of the urothelium of at least T2-4, Nx, Mx stage. Mixed histologies will be allowed (e.g. squamous differentiation) as long as a transitional cell component is present.
- Clinical plans for surgery (with or without chemotherapy), radiation therapy, or chemotherapy.
- Participants must not have any condition which in the investigator's opinion may compromise the feasibility of completing the study.
- Subject must be 18 years of age or older
- Subject must be willing to have up to 4 peripheral blood samples obtained over a 6 month period of study.
- Prior therapies for bladder cancer will be allowed if patient currently has muscle-invasive or metastatic bladder cancer despite the previous treatments.
- Predicted life expectancy of \> 12 weeks.
Exclusion
- Subjects who are unwilling or unable to comply with the study guidelines as determined by the principal investigator.
Key Trial Info
Start Date :
November 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2013
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT00829920
Start Date
November 1 2008
End Date
February 1 2013
Last Update
June 25 2013
Active Locations (1)
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1
University of Colorado Hospital
Aurora, Colorado, United States, 80010