Status:
UNKNOWN
Collaborative Systematic Overview of Randomised Controlled Trials of Beta-Blockers in the Treatment of Heart Failure
Lead Sponsor:
Royal Brompton & Harefield NHS Foundation Trust
Collaborating Sponsors:
University of Oxford
Conditions:
Heart Failure
Eligibility:
All Genders
Brief Summary
Several large trials have shown that beta-blocker treatment reduces the risk of death and hospital admission in patients with symptomatic heart failure. Unfortunately, survey data suggests relatively ...
Eligibility Criteria
Inclusion
- Randomised control trials of beta-blocker versus control in patients with documented heart failure
- Unconfounded trials only (in which one treatment group differed from another only by the beta-blocker therapy of interest)
- Randomization process precluded prior knowledge of the next treatment (for example trials in which treatment allocation was alternate or based on odd or even dates would not be included)
Exclusion
- Trial sample size of less than 300 patients
Key Trial Info
Start Date :
August 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2012
Estimated Enrollment :
18240 Patients enrolled
Trial Details
Trial ID
NCT00832442
Start Date
August 1 2008
End Date
December 1 2012
Last Update
May 9 2012
Active Locations (2)
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1
Clinical Trials & Evaluation Unit, Royal Brompton Hospital
London, United Kingdom
2
Centre for Statistics in Medicine, University of Oxford
Oxford, United Kingdom