Status:
COMPLETED
Orbitofrontal Cortex (OFC) Influence on Addictive Medication Overuse Headache (MOH) Deriving From Migraine
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Medication Overuse Headache
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Medication Overuse Headache (MOH) is an illness affecting about 1,5 % of the general population. It is characterized by chronic headache occurring for at least 15 days a month, by a use of antimigrain...
Detailed Description
We recently explored cerebral metabolism in these MOH patients using (18F)FDG-PET (Fluoro Dexoxy Glucose Positon Emission Tomography) comparing them with controls. Results showed a hypometabolism in t...
Eligibility Criteria
Inclusion
- Inclusion Criteria for patients :
- older than eighteen years
- suffering from MOH (ICHD-II criteria)
- French speaking
- who wish to go on a withdrawal procedure
- Exclusion Criteria :
- pregnant women or women of child bearing age who are not using contraception
- post traumatic headaches
- illnesses interfering with the central nervous system functionning
- psychotic disorder or current major depressive episode
- contraindication for PET or MRI (Magnetic Resonnance Imaging)
- contraindication for all prophylactic treatment for migraine
Exclusion
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2012
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT00833209
Start Date
February 1 2009
End Date
May 1 2012
Last Update
August 1 2012
Active Locations (2)
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1
C.H.U. de Bordeaux - Groupe Hospitalier Pellegrin - Service Médecine nucléaire
Bordeaux, France, 33076
2
CHU de Bordeaux - Hôpital Tastet Girard Centre Anti douleur
Bordeaux, France, 33076