Status:
COMPLETED
Effect of Preoperative Chemoradiotherapy on Exercise Capacity as Measured by Cardiopulmonary Exercise Testing
Lead Sponsor:
Imperial College London
Conditions:
Colorectal Cancer
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
This study will investigate the effect of preoperative chemoradiotherapy on exercise capacity as measured by cardiopulmonary exercise testing in patients with colorectal cancer.
Detailed Description
Chemoradiotherapy is associated with adverse effects. Patients with certain colorectal cancers undergo chemoradiotherapy prior to surgical resection. We intend to assess patient exercise capacity befo...
Eligibility Criteria
Inclusion
- Age greater than 65
- Colorectal cancer requiring preoperative chemoradiotherapy
Exclusion
- Inability to walk, or exercise on a bicycle or treadmill
- Inability to understand instructions for CPET testing
- ASA grade 4 or 5 (indicating severe cardiovascular co-morbidity and not expected to survive surgery)
- Contraindications to Exercise Testing
- Myocardial infarction occurring 10 days or less before CPX testing
- Symptomatic arrythmias
- Left Main Stem coronary disease of \>50%
- Severe hypertension (SBP\>180mmHg)
- Resting SpO2 \<85%
- Acute cardiac inflammatory conditions (myocarditis, pericarditis)
- Unstable angina with symptoms within 4 days
- Dissecting aneurysm of aorta
- Acute pyrexial illness
- Thyrotoxicosis
- Syncopal episodes
- Lower limb thrombosis (arterial or venous)
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2011
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00833508
Start Date
January 1 2009
End Date
October 1 2011
Last Update
February 17 2016
Active Locations (1)
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1
Imperial NHS Trust, St Mary's Hospital, Praed Street
London, United Kingdom, W2 1NY