Status:
COMPLETED
Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Depression
Eligibility:
All Genders
20-60 years
Phase:
PHASE4
Brief Summary
This study will determine whether the drug metformin improves the effects of traditional antidepressant medications in people who are overweight.
Detailed Description
Current depression treatments are not effective for approximately one-half of overweight people, and depression eventually returns in approximately one-third of those overweight people whose initial t...
Eligibility Criteria
Inclusion
- Body mass index (BMI) greater than 28.7
- Positive screening for depression
- Must live within 100 miles of the St. Louis metropolitan area
Exclusion
- Pregnant or breastfeeding
- Known hypersensitivity to sertraline or metformin
- Recent history of heart attack or unstable heart disease
- Severe liver disease or kidney impairment, defined by a serum creatine level above 3 mg/dL
- Psychiatric disorder thought to affect management, such as schizophrenia, or alcohol or drug dependence
Key Trial Info
Start Date :
September 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
206 Patients enrolled
Trial Details
Trial ID
NCT00834652
Start Date
September 1 2007
End Date
May 1 2013
Last Update
September 10 2018
Active Locations (1)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63110