Status:
COMPLETED
Rivastigmine in the Treatment of Postoperative Delirium: a Pilot Clinical Trial
Lead Sponsor:
NYU Langone Health
Collaborating Sponsors:
Novartis
Conditions:
Delirium
Postoperative Cognitive Dysfunction
Eligibility:
All Genders
65+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether preoperative administration of Rivastigmine prevents the incidence of postoperative delirium in patients undergoing major surgery as well as postopera...
Detailed Description
Postoperative delirium (POD) and Postoperative cognitive dysfunction (POCD) are common significant postoperative complications in elderly patients. A reduction of postoperative complications would lea...
Eligibility Criteria
Inclusion
- 65 ≥ y.o. undergoing major elective surgery over 2 hours in length with one or more of the following:
- Preoperative cognitive impairment
- Age \> 70 y.o.
- Use of psychoactive medications
- History of prior delirium
- Severe illness/co-morbidity
Exclusion
- Delirium on admission Profound dementia No spoken/written English An emergent procedure Hypersensitivity to Rivastigmine
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00835159
Start Date
December 1 2008
End Date
October 1 2010
Last Update
February 9 2015
Active Locations (1)
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1
NYU Langone Medical Center, Department of Anesthesiology 550 First Avenue, RR-603
New York, New York, United States, 10016