Status:
COMPLETED
Treatment Trial for Psychogenic Nonepileptic Seizures
Lead Sponsor:
Rhode Island Hospital
Collaborating Sponsors:
American Epilepsy Society
Epilepsy Foundation
Conditions:
Convulsion, Non-Epileptic
Conversion Disorder
Eligibility:
All Genders
18-95 years
Phase:
PHASE4
Brief Summary
The investigators propose that patients who receive targeted pharmacotherapy (sertraline) or focused psychotherapy (cognitive behavioral therapy-informed psychotherapy (CBT-ip) for NES) or combined tr...
Detailed Description
This is a pilot, prospective, multi-center, randomized controlled trial, that assesses the number of NES in patients treated with either flexible dose sertraline (Zoloft), cognitive behavioral therapy...
Eligibility Criteria
Inclusion
- Video electroencephalogram (EEG) confirmed diagnosis of NES
- Have at least one nonepileptic seizure per month
- Able to complete self report symptom scales
- Not receiving optimized sertraline
Exclusion
- Equivocal EEG findings
- using monoamine oxidase inhibitors (MAOIs), pimozide, or sumatriptan
- allergy/sensitivity to sertraline
- current alcohol/drug dependence
- serious medical illness requiring current hospitalization
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT00835627
Start Date
September 1 2008
End Date
June 1 2013
Last Update
November 10 2014
Active Locations (3)
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1
Stanford University
Stanford, California, United States, 94305
2
University of Cincinnati
Cincinnati, Ohio, United States, 45267
3
Rhode Island Hospital
Providence, Rhode Island, United States, 02903