Status:
UNKNOWN
Oral Aprepitant and Lower Dose Dexamethasone Versus Aprepitant Alone for Preventing Postoperative Nausea and Vomiting (PONV) After Elective Laparoscopic Surgeries
Lead Sponsor:
Main Line Health
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Drexel University College of Medicine
Conditions:
Nausea
Vomiting
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The combination of aprepitant and lower dose dexamethasone is superior to aprepitant alone with respect to the proportion of patients with a complete response (no vomiting and no use of rescue therapy...
Detailed Description
Postoperative Nausea and Vomiting (PONV) is a serious and common (50%-70%) complication of laparoscopic abdominal surgery. PONV is multifactorial, and the treatment is multimodal. Preoperative treatme...
Eligibility Criteria
Inclusion
- at least 18 years old
- ASA physical status I-III
- must have at least 2 risk factors for PONV
Exclusion
- pregnant or breast feeding patients
- antiemetic medication in previous 24 hours
- allergy or other contraindication to study medications
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00835965
Start Date
February 1 2009
Last Update
February 4 2009
Active Locations (1)
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1
Lankenau Hospital
Wynnewood, Pennsylvania, United States, 19096