Status:
RECRUITING
Genetics of Type 2 Diabetes in West Africans
Lead Sponsor:
National Human Genome Research Institute (NHGRI)
Conditions:
Hypertension
Diabetes
Eligibility:
All Genders
18-120 years
Brief Summary
Background: * Type 2 diabetes (T2D) and associated complications are major contributors to the global disease burden. T2D is already a major health threat in populations in developed countries and is...
Detailed Description
Study Description: This protocol is designed to study the genetic basis of Type 2 Diabetes (T2D) and related conditions in Africa. Objectives: Primary Objective: To conduct genetic association stud...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- As our primary interest is in T2D, it is important to exclude individuals who may have diabetes of another etiology. Elevated blood glucose in individuals 25 years old or younger is unlikely (in West Africa) to result from T2D and may reflect Type 1 Diabetes. Therefore, only individuals older than 25 years will be included in this study.
- We are seeking to enroll persons without T2D or with previously or newly diagnosed T2D. Previously diagnosed cases will be determined by self-report of being treated with oral medication or insulin. Newly diagnosed cases will be determined by fasting blood glucose value \>= 126 mg/dl on more than one occasion. Individuals who have elevated blood glucose during their initial reading will be asked to return to the study site for a second test. If this test also has a fasting blood glucose value \>= 126 mg/dl, then they will be considered a new case. The control group will be individuals with no report of T2D diagnosis and fasting plasma glucose (FPG)\< 126 mg/dl.
- Only unrelated individuals will be included in this phase of the study to avoid confounding genetic association studies by relatedness in the study population.
- EXCLUSION CRITERIA:
- An individual who meets any of the following criteria will be excluded from participation in this study:
- Incarceration.
- Lack capacity to consent to research participation.
- Pregnancy.
Exclusion
Key Trial Info
Start Date :
February 3 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
10000 Patients enrolled
Trial Details
Trial ID
NCT00837122
Start Date
February 3 2009
Last Update
January 5 2026
Active Locations (5)
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1
University of Ghana
Accra, Ghana
2
University of Science and Tech
Kumasi, Ghana
3
University of Nigeria
Enugu, Nigeria
4
University of Ibadan
Ibadan, Nigeria