Status:
COMPLETED
Adverse Effects of RBC Transfusions: A Unifying Hypothesis
Lead Sponsor:
Emory University
Conditions:
Healthy Volunteers
Eligibility:
All Genders
21-80 years
Phase:
PHASE2
Brief Summary
Transfusion of red blood cells is often used in critically ill patients with low red blood cell counts to prevent disease progression and death. Recent studies suggest that the use of "aged" versus "f...
Detailed Description
Transfusion of red blood cells (RBCs) is often effective at preventing morbidity and mortality in anemic patients. In contrast, recent studies indicate that some RBC components may have functional def...
Eligibility Criteria
Inclusion
- Aim 1:
- Healthy male or female volunteers (age 21-60 years)
- Must meet guidelines for blood donors including:
- standard blood donor history questionnaire
- body weight of at least 110 lbs
- hemoglobin concentration of at least 12.5 gm/dL
- body temperature of no more than 99.5 oF
- pulse of 50-100 bpm
- blood pressure \< 180/100
- test negative for the standard battery of blood donor screening tests (anti-HIV, HIV RNA, anti-HCV, HCV RNA, HBsAg, anti-HBc, anti-HTLV-I/II, and WNV RNA)
- Aim 1:
Exclusion
- Failure to pass the blood donor history questionnaire
- Positive results on the standard battery of blood donor screening tests
- Failure to meet criteria for donation
- Aim 2:
- Inclusion Criteria:
- Healthy male or female volunteers (age 21-80 years)
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2013
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00838331
Start Date
April 1 2009
End Date
October 1 2013
Last Update
March 6 2015
Active Locations (1)
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1
Emory University
Atlanta, Georgia, United States, 30322