Status:
COMPLETED
Clopidogrel Efficacy and Acute Coronary Syndromes
Lead Sponsor:
Charles University, Czech Republic
Conditions:
Acute Myocardial Infarction
Eligibility:
All Genders
18-90 years
Brief Summary
The purpose of this study is to compare clopidogrel effectiveness between severe hemodynamically unstable versus stable patients with acute myocardial infarction.
Detailed Description
Clopidogrel exists in oral form only. As a prodrug, it has to be metabolized to the active form by cytochrome system in the liver. Both facts could lead to lower efficacy of the drug in hemodynamicall...
Eligibility Criteria
Inclusion
- Inclusion Criteria for unstable group:
- acute STEMI
- mechanical ventilation
- the need for catecholamine support.
- Inclusion Criteria for stable group:
- acute myocardial infarction
- Exclusion Criteria for any:
- previous treatment with clopidogrel
- clopidogrel administration during transport by ambulance
- known intolerance to clopidogrel
- history of thrombocytopenia (\<150,000 platelets/ml)
- pre-existing liver disease
Exclusion
Key Trial Info
Start Date :
June 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00839267
Start Date
June 1 2006
End Date
December 1 2008
Last Update
February 10 2009
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Cardiocenter, 3rd Medical School, Charles University and University Hospital Kralovske Vinohrady
Prague, Czechia, 10034