Status:
TERMINATED
Efficacy of Long-term Ribavirin in Non-responders With Chronic Hepatitis C and Advanced Fibrosis
Lead Sponsor:
Hospital Universitario Ramon y Cajal
Conditions:
Chronic Hepatitis C
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
The rate of sustained virological response to a course of standard antiviral therapy (peg-interferon plus ribavirin) of patients with chronic hepatitis C infected by genotype 1 with advanced fibrosis ...
Eligibility Criteria
Inclusion
- HCV RNA in serum
- AST/ALT greater than the upper limit of normal range
- HVPG \>5 mm Hg
- Non-response or contraindication to a standard course of antiviral therapy
Exclusion
- Active alcoholism
- HIV infection
- Serum creatinine \>1.2 mg/dl, hemoglobin \<11 g/dl, hemolysis, symptomatic ischemic heart disease or cerebrovascular disease
- Decompensated chronic liver disease
- Pregnancy
- Hypersensitivity to the drugs of the study
- Severe concomitant disease
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00840489
Start Date
January 1 2009
End Date
December 1 2012
Last Update
January 31 2013
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
Hospital General Universitario Gregorio Marañón
Madrid, Madrid, Spain, 28007
2
Hospital Universitario Ramon y Cajal
Madrid, Madrid, Spain, 28034
3
Hospital Universitario Puerta de Hierro-Majadahonda
Madrid, Madrid, Spain, 28222