Status:
TERMINATED
Intravenous Lidocaine and Postoperative Outcomes After Cardiac Surgery
Lead Sponsor:
The Cleveland Clinic
Conditions:
Atrial Fibrillation
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
This study is being done to determine if lidocaine, administered during surgery and for 24 hours after surgery can reduce inflammation, thereby reducing the risk of atrial fibrillation and 30 day mort...
Detailed Description
Subjects undergoing cardiac surgery are randomized into one of two groups. * Group 1: Intravenous Lidocaine Group * Group 2: Intravenous placebo Group Either Lidocaine or placebo is administered thr...
Eligibility Criteria
Inclusion
- Age 18-90 years old
- Scheduled for cardiac surgery requiring cardiopulmonary bypass
- Written informed consent
Exclusion
- Off-pump surgical procedures
- Anticipated deep hypothermic circulatory arrest
- Any contraindications to the proposed interventions including lidocaine allergy
- History of preoperative atrial fibrillation
- Baseline Screening revealing preexisting dementia or delirium
- Preoperative liver failure defined as Child-Pugh Score \> 6
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 15 2014
Estimated Enrollment :
123 Patients enrolled
Trial Details
Trial ID
NCT00840918
Start Date
February 1 2009
End Date
December 15 2014
Last Update
March 29 2019
Active Locations (1)
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1
SAL Hospital
Ahmedabad, Gujarat, India, 380 054