Status:
COMPLETED
Long Term Effects of Erythrocyte Lysis
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Sickle Cell Disease
Hemolytic Anemia
Eligibility:
All Genders
5+ years
Brief Summary
In this prospective observational trial, participants with chronic hemolysis will be assessed with echocardiogram for elevated tricuspid jet velocity and other evidence of pulmonary hypertension. Part...
Detailed Description
1. The study will investigate the relationship between tricuspid regurgitation jet velocity (TRV) and intravascular hemolysis, as measured by serum lactate dehydrogenase (LDH), in untreated children w...
Eligibility Criteria
Inclusion
- Established Diagnosis of Hemolysis
- Sickle Cell Disease (e.g., HbSS, HbS/β-thalassemia, HbSC)
- Other conditions with hemolysis (e.g., RBC membranopathies, enzymopathies, unstable hemoglobinopathies, PNH)
- Age
- SCD participants: 5 years of age up to 19th birthday
- All other participants: 5 years of age and up (no age limit)
Exclusion
- Previous cardiac surgery
- Known left ventricle dysfunction (i.e. shortening fraction \< 28%)
- Known right sided congenital heart defect such as atrial septal defect or pulmonary valve stenosis
Key Trial Info
Start Date :
March 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
390 Patients enrolled
Trial Details
Trial ID
NCT00842621
Start Date
March 1 2009
End Date
June 1 2016
Last Update
June 27 2016
Active Locations (1)
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1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38115