Status:
COMPLETED
Famotidine Compared With Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion
Lead Sponsor:
Ruttonjee Hospital
Conditions:
Peptic Ulcer/Erosions
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Low-dose aspirin can prevent cerebral and cardiovascular accidents in individuals with symptomatic atherothrombotic disease, but its use is frequently limited by gastrointestinal side effects. The po...
Detailed Description
Low-dose aspirin can prevent cerebral and cardiovascular accidents in individuals with symptomatic atherothrombotic disease . Its use is frequently limited by gastrointestinal side effects, ranging fr...
Eligibility Criteria
Inclusion
- upper GIB or dyspepsia due to peptic ulcers / erosions while receiving low-dose aspirin with a daily dose ranging from 80 mg to 320 mg
- endoscopy revealed a gastric or duodenal ulcers of 3 mm or more in diameter with unequivocal depth, or more than 5 erosions in the stomach or duodenum
- they required continuous low-dose aspirin for the secondary prevention of coronary heart disease, peripheral vascular disease and ischemic stroke or transient ischemic attacks
- 18 years old or older.
Exclusion
- concurrent erosive or ulcerative esophagitis
- pyloric stenosis
- previous gastric or duodenal surgery other than oversewing of a perforation
- thrombocytopenia
- renal failure with estimated creatinine clearance less than 10 ml / min
- active cancer
- known allergic to aspirin, famotidine or pantoprazole
- pregnancy, lactation, child-bearing potential in the absence of contraception
- psychosomatic disorder
- planned co-prescription of nonsteriodal anti-inflammatory drugs corticosteriod, or anticoagulant
- disorders that might modify the absorption of study drugs
Key Trial Info
Start Date :
August 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
161 Patients enrolled
Trial Details
Trial ID
NCT00843063
Start Date
August 1 2004
End Date
December 1 2008
Last Update
February 13 2009
Active Locations (1)
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1
Ruttonjee Hospital
Wan Chai, Hong Kong, China