Status:
COMPLETED
Characterization of the Incretinpathy in Type 2 Diabetes Initiated After Sixty Years Old
Lead Sponsor:
University of Campinas, Brazil
Conditions:
Diabetes Mellitus, Type 2
Insulin Resistance
Eligibility:
All Genders
35-80 years
Brief Summary
Type 2 diabetes (T2DM) is characterized by hyperglycemia, insulin resistance, absolute or relative insulin deficiency, hyperglucagonemia, increased hepatic glucose production, frequently accelerated g...
Eligibility Criteria
Inclusion
- Stable weight (\<5% variation) within the last three months
- Age: 35 to 50 years old for middle-age group, and 65 to 80 y old for elderly group
- Body mass index (BMI): 20 to 29.9kg/m2
- T2DM with diagnosis above 35 years and less than 5 years (Middle-age group)
- T2DM with diagnosis above 65 years and less than 5 years (Elderly group)
- Use of oral antidiabetic drugs (that must at stable dose within the last 3 months)
- Not have participated in any study of intervention with drugs in the last six months.
Exclusion
- Use of estrogen, progestogen, active antipsychotics and systemic corticosteroids
- Use of DPP-IV inhibitors and incretin mimetics (current or within 1 month before)
- Continuous use of insulin or glitazone
- Hepatic cirrhosis, renal failure or any clinical condition with impaired insulin sensitivity
- Smoking
- Obesity
- Uncontrolled systemic or disabling diseases
- T2DM treated by non pharmacological methods
- Patients submitted to bariatric surgery
- Latent autoimmune diabetes of the adult (positive anti-GAD antibodies)
Key Trial Info
Start Date :
July 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00843232
Start Date
July 1 2009
End Date
September 1 2010
Last Update
February 4 2011
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
LIMED (Laboratory of Investigation of Metabolism and Diabetes)/GASTROCENTRO/Univeristy of Campinas (UNICAMP)
Campinas, São Paulo, Brazil