Status:
COMPLETED
Expiratory Muscle Training in Patients With Parkinson's Disease
Lead Sponsor:
University of Florida
Conditions:
Parkinson's Disease
Eligibility:
All Genders
35-85 years
Phase:
PHASE1
PHASE2
Brief Summary
Respiratory difficulty is one of the primary factors leading to death in patients with Idiopathic Parkinson's Disease (IPD). The progressive degeneration of a family of segregated motor and non-motor ...
Eligibility Criteria
Inclusion
- Adults between the age of 35 and 85 years.
- Diagnosis of Idiopathic Parkinson's Disease (either tremor-predominant or rigid- predominant) by their neurologist.
- Disability level of II, III, or IV (Hoehn \& Yahr, 1976) as indicated in their most recent neurological evaluation.
- Forced Expiratory Volumes (FEV1) and forced vital capacity (FVC) within normative range for age and sex determined by a pulmonary function screening.
- Persons who are able to maintain their current level of physical activity (including both aerobic exercise and weightlifting) throughout the entire training period.
- \*Subjects will be asked to report any significant changes in their level of activity throughout their participation in the study in regards to intensity and frequency of exercise (i.e. a sedentary person begins exercising three to four days per week).
- Completion of the informed consent to participate in the study.
Exclusion
- Other neurological disorders
- Positive history of any of the following conditions:
- Gastrointestinal disease
- Gastro-esophageal surgery
- Head or neck cancer
- History of breathing disorders or diseases (e.g., Asthma, chronic obstructive pulmonary disease (COPD)).
- Untreated hypertension
- Heart disease
- History of smoking in the last five years
- Failing the screening test of pulmonary functions (e.g., FEV1/FVC \< 75%)
- Difficulty in complying with the training protocol due to neuropsychological dysfunction (e.g., severe depression).
- Other illness that would prevent patient from completing the protocol.
Key Trial Info
Start Date :
January 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00843739
Start Date
January 1 2004
End Date
December 1 2008
Last Update
September 20 2011
Active Locations (1)
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1
University of Florida
Gainesville, Florida, United States, 32611