Status:
WITHDRAWN
Asthma Exacerbation and Helium-3 MRI
Lead Sponsor:
University of Massachusetts, Worcester
Conditions:
Asthma Exacerbation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this research is to use Helium-3 MRI to see the changes in airflow of the lungs at different times of an attack. These three stages are immediately after the attack, 1 month later and 4-6 ...
Detailed Description
Asthma is a pulmonary disorder that affects millions of people each year. The exact method of exacerbation is still under some discussion. Currently there is no cure for the disorder but treatment is ...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- At least 18 years old
- Able to speak and read English
- Acute asthma exacerbation, defined as requirement for hospitalization or emergent outpatient visit, and treatment with high dose corticosteroids ( 40mg prednisone or equivalent)
- FEV1 \< 80% predicted on the day of MRI
- Attending physician agrees that patient is safe to participate on the day of the MRI scan
- Exclusion Criteria
- Evidence of pneumonia, based on chest radiograph obtained within 24 hours of enrollment (if performed)
- Documented fever or requirement for antibiotics
- Unable to hold breath for 10 seconds
- Active smoker or history of at least 10 pack years cigarette smoking
- Chest radiograph with active pulmonary disease, except for changes expected with asthma (hyperinflation, subsegmental atelectasis)
- Admission to ICU
- For inpatients: contraindication to leaving hospital room for MRI as determined by Attending physician and RN on day of MRI
- Any other concurrent active pulmonary disease or other unstable or active medical condition (including suspected active coronary ischemia, acute bleeding), as determined by Attending physician
- Pregnancy as self reported
- Need for cardiac monitoring
- Need supplemental oxygen at an amount of 4L/min or a facemask
Exclusion
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00846014
Start Date
January 1 2009
End Date
August 1 2011
Last Update
September 20 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
UMASS Medical School Advanced MRI Center
Worcester, Massachusetts, United States