Status:
ACTIVE_NOT_RECRUITING
Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Favorable-Risk Hodgkin Lymphoma
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Hodgkin Lymphoma
Eligibility:
All Genders
Up to 21 years
Phase:
PHASE2
Brief Summary
This phase II trial is studying how well combination chemotherapy with or without radiation therapy works in treating young patients with favorable-risk Hodgkin lymphoma. Drugs used in chemotherapy, s...
Detailed Description
Patients receive doxorubicin hydrochloride intravenously (IV) and vinblastine IV on day 1 of weeks 1, 3, 5, and 7; mechlorethamine hydrochloride IV on day 1 of weeks 1 and 5; vincristine sulfate IV an...
Eligibility Criteria
Inclusion
- Histologically confirmed, previously untreated Hodgkin lymphoma.
- Age: Participants must be 21 years of age or younger
- Stage must be classified as one of the following:
- Ann Arbor stage IA or IIA with:
- Non-bulky mediastinal disease (\< 33% mediastinal to thoracic ratio on CXR)
- \< 3 nodal regions involved on the same side of the diaphragm
- No "E" lesion
- Female patients who are post-menarchal must have a negative pregnancy test. Patients of reproductive potential must agree to use an effective contraceptive method.
- Signed informed consent
- If re-evaluation of a patient's disease shows intermediate risk features, the patient will be removed from the HOD08.
Exclusion
- Intermediate or High risk disease, defined as Stage IB, any III or IV or IA/IIA with "E" lesion(s), 3 or more nodal sites involved, or bulky mediastinal adenopathy
Key Trial Info
Start Date :
June 5 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2028
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT00846742
Start Date
June 5 2009
End Date
October 1 2028
Last Update
December 8 2025
Active Locations (6)
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1
Packard Children's Hospital, Stanford University
Palo Alto, California, United States, 94304
2
Rady Children's Hospital- San Diego
San Diego, California, United States, 92123
3
Children's Hospital of Illinois at OSF St. Francis Medical Center
Peoria, Illinois, United States, 61637
4
Maine Children's Cancer Program (MCCP)
Scarborough, Maine, United States, 04074