Status:
COMPLETED
Neuromuscular Transmission in Amyotrophic Lateral Sclerosis
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Association pour la Recherche sur la Sclérose Latérale Amyotrophique
Association Française contre les Myopathies (AFM), Paris
Conditions:
Amyotrophic Lateral Sclerosis
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Consistent data suggest that neuromuscular transmission is impaired in ALS patients. Neuromuscular junctions dysfunction may appear very early in the disease, as shown by data in animal models. The pa...
Detailed Description
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder involving motor neurons of the motor cortex, brain stem and spinal cord. Its pathogenesis remains unknown, and the only ...
Eligibility Criteria
Inclusion
- ALS patients:
- Inclusion criteria :
- Aged 18 to 75 (inclusive)
- Possible, probable (clinically or laboratory) or definite ALS according to the revised El Escorial criteria
- Duration of the disease of less then 12 months
- Willing and able to provide a written informed consent
- With french social insurance affiliation
- Exclusion criteria :
- Cognitive changes or psychiatric condition, inability to give informed consent
- patient unable to contact or to be contacted by the investigator in case of emergency
- women who are pregnant or nursing
- concomitant medication contraindicating muscular biopsy (platelet suppressive agents if treatment can not medically be stopped 2 weeks before surgical procedure, oral anticoagulant therapy)
- medical condition contraindicating muscular biopsy (hypo-coagulative disease, allergy to anaesthetic drugs)
- medical condition susceptible to influence on EMG examination (concomitant neurological or rheumatological disease)
- Controls:
- adult patients (minimum 18y) without neuromuscular disease
- undergoing elbow surgery for local joint or bone disease
Exclusion
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00847847
Start Date
March 1 2009
End Date
April 1 2012
Last Update
November 19 2012
Active Locations (1)
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1
Bruneteau Gaelle
Paris, France, 75003