Status:
COMPLETED
Prospective Study With FLOT in Patients With Locally Advanced, Limited Metastatic or Extensive Metastatic Adenocarcinoma of the Stomach or Esophagogastric Junction
Lead Sponsor:
Krankenhaus Nordwest
Conditions:
Gastric Cancer
Adenocarcinoma of the Esophagogastric Junction
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Patients with locally advanced or metastatic gastric carcinoma or carcinoma of the esophagogastric junction without prior palliative therapy will be treated with 8 cycles of the FLOT scheme (up to 12 ...
Detailed Description
250 patients with locally advanced or metastatic gastric carcinoma or carcinoma of the esophagogastric junction without prior palliative therapy will be treated with 8 cycles of the FLOT scheme (up to...
Eligibility Criteria
Inclusion
- Metastatic or locally advanced gastric cancer or adenocarcinoma of the esophagogastric junction
- No prior chemotherapy in metastatic state
- Adequate blood and biochemistry parameters
Exclusion
- Hypersensitivity for 5-FU, Leucovorin, Oxaliplatin or Docetaxel
- KHK, cardiomyopathy or cardiac insufficiency
- Malignancy \<5 years ago
- Brain metastases
- Severe internal disease or inadequate blood and biochemistry parameters
- Pregnancy and lactation
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2016
Estimated Enrollment :
252 Patients enrolled
Trial Details
Trial ID
NCT00849615
Start Date
February 1 2009
End Date
January 1 2016
Last Update
April 6 2016
Active Locations (1)
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1
Krankenhaus Nordwest
Frankfurt, Germany, 60488