Status:
TERMINATED
Enhancing the Response to Rehabilitation After Stroke Using Repetitive Transcranial Magnetic Stimulation (rTMS)
Lead Sponsor:
McGill University Health Centre/Research Institute of the McGill University Health Centre
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Stroke
Eligibility:
All Genders
19+ years
Phase:
PHASE2
Brief Summary
Weakness of the arm and hand results in long-term disability for many persons who suffer a stroke. After the initial recovery phase, only limited gains are achieved by retraining the weak limb to perf...
Eligibility Criteria
Inclusion
- first clinical stroke involving the middle cerebral artery confirmed by CT or MRI scan during acute care at the MUHC, or second stroke involving the same hemisphere when there were no clinical residual effects from the first stroke;
- cortical or subcortical stroke resulting in hemiparesis;
- at least 3 months post-stroke;
- discharged from standard rehabilitation;
- able to provide informed consent, to follow instructions and participate in therapy, as evidenced by Mini Mental State Exam score \> 14;
- able to understand instructions in English or French.
Exclusion
- minimal or no residual upper extremity motor impairment;
- severe upper extremity motor impairment as indicated by inability to produce any voluntary contraction of intrinsic hand muscles; severe cognitive impairment in language or attention sufficient to impair communication during the consenting or intervention procedures (score \< 14 on the Mini Mental Status Exam);
- other central nervous system disorder or peripheral neuropathy of the upper extremity;
- pain, spasticity, or other complications that would prevent participation in the intervention;
- history of seizure confirmed by interview and medical chart review;
- comorbidity such as Parkinson's disease, osteoarthritis, or cancer, precluding full participation in the assessments and in the experimental intervention;
- other conditions that increase the risk of side effects due to rTMS procedures: metal in cranium, intracardiac line, increased intracranial pressure, pregnancy, cardiac pacemaker, medication pump, tricyclic antidepressants, neuroleptics, history of seizure in the immediate family
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT00850408
Start Date
June 1 2008
End Date
March 1 2011
Last Update
April 24 2013
Active Locations (1)
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1
Royal Victoria Hospital
Montreal, Quebec, Canada, H3A 1A1