Status:
COMPLETED
Role of Bone in Knee Osteoarthritis (OA)
Lead Sponsor:
The New England Baptist Hospital
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of the study is to investigate protein and gene expression among damaged knee tissues. We will perform MRI's on subjects prior to total knee replacement to identify the location of bone ma...
Detailed Description
BACKGROUND AND SIGNIFICANCE: Although the presence of bone marrow lesions (BML) on MRI is strongly associated with osteoarthritis (OA) progression and pain in some studies, the mechanism for this rel...
Eligibility Criteria
Inclusion
- subjects having primary knee replacement surgery with 1 participating surgeon at NEBH (principal investigator)
Exclusion
- subjects having a revision knee replacement instead of a primary knee replacement
- contraindications for MRI
- pregnancy
Key Trial Info
Start Date :
July 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2013
Estimated Enrollment :
101 Patients enrolled
Trial Details
Trial ID
NCT00850538
Start Date
July 1 2008
End Date
April 1 2013
Last Update
December 4 2015
Active Locations (1)
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1
University of Sydney
Sydney, New South Wales, Australia, 02120