Status:
WITHDRAWN
Adjunct Dexmedetomidine (Precedex®) Therapy Impact on Sedative and Analgesic Requirement
Lead Sponsor:
Avera McKennan Hospital & University Health Center
Conditions:
Sedation
Analgesia
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Assess impact of increasing dose of dexmedetomidine on total daily dose of fentanyl and propofol while maintaining sedation in a mechanically ventilated patient in a general medical intensive care uni...
Detailed Description
Patients identified by selection criteria within 48 hours of intubation will be randomly assigned to one of three study arms: dexmedetomidine 0.2 mcg/kg/hr, dexmedetomidine 0.6 mcg/kg/hr, or placebo. ...
Eligibility Criteria
Inclusion
- surgical, medical, or trauma patients requiring sedation for mechanical ventilation
- age 18-80
- Anticipated ventilation time of \> 24 hrs
- Reasonable chance of recovery
Exclusion
- Severe COPD
- Chronic immunosuppression (equivalent to prednisone 7.5 mg daily or higher)
- Heart block
- Bradycardia
- Significant head injury
- Goal SAS score of 1-2
- Severe hepatic impairment
- Hypertriglyceridemia
- Allergy to dexmedetomidine, fentanyl, propofol or eggs
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2009
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00852046
Start Date
February 1 2009
End Date
March 1 2009
Last Update
October 6 2011
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