Status:
COMPLETED
Lipoprotein Effects of Substituting Beef Protein for Carbohydrate
Lead Sponsor:
UCSF Benioff Children's Hospital Oakland
Collaborating Sponsors:
National Cattlemen's Beef Association, a contractor to the Beef Checkoff
Conditions:
Healthy
Cardiovascular Disease
Eligibility:
MALE
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to test whether replacing dietary carbohydrate with protein, using beef as the primarily source of protein, will improve risk factors for cardiovascular disease.
Detailed Description
The primary aim of this study is to test the hypothesis that replacing dietary carbohydrate with protein, using beef as the primarily source of protein, will have beneficial effects on components of a...
Eligibility Criteria
Inclusion
- Blood pressure less than 150/90
- Body mass index (BMI)≥ 20 and ≤ 35 kg/m2
- Non-smoker
- Agrees not to consume alcohol during the study
- Agrees to abstain from taking dietary supplements during the study
- LDL-cholesterol and total cholesterol \< 95th percentile for age and sex
- Fasting triglycerides \< 500 mg/dL
- Fasting glucose concentration \< 126 mg/dL
- Hematocrit (HCT) ≥ 36%
- At least three months of a weight-stable state (± 3% of body weight)
Exclusion
- Personal history of coronary heart disease, cerebrovascular disease, peripheral vascular disease, diabetes, lung disease, bleeding disorder, liver or renal disease, HIV or of cancer (other than skin cancer) in the last five years
- Taking drugs known to affect lipid metabolism or insulin resistance, hormones, or the blood thinning agent warfarin
- Abnormal thyroid stimulating hormone (TSH)
- Strength trains with resistance weights more than four hours per week
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
67 Patients enrolled
Trial Details
Trial ID
NCT00852267
Start Date
January 1 2008
End Date
December 1 2009
Last Update
December 24 2020
Active Locations (1)
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1
Cholesterol Research Center
Berkeley, California, United States, 94705