Status:
COMPLETED
Sedation and Pain (The Effect of IV Sedation on Pain Perception)
Lead Sponsor:
University of Alabama at Birmingham
Collaborating Sponsors:
American Society of Regional Anesthesia
Conditions:
Pain
Eligibility:
All Genders
19-40 years
Phase:
NA
Brief Summary
The investigators propose to evaluate the potential effect of sedation on pain perception in two ways, by asking for a participant's pain rating(subjective) and by evaluating a subject's brain activat...
Detailed Description
We propose to contrast and compare the effect of propofol and midazolam, two GABA-related sedative drugs, and dexmedetomidine, an alpha-2 adrenergic agonist, on pain perception in human volunteers by ...
Eligibility Criteria
Inclusion
- Healthy subjects
- 19 years or older able to follow study instructions
Exclusion
- Age less than 19 or greater than 40
- Pregnant female
- Obesity (BMI \> or =35)
- Non-English speaking/reading participants
- Sleep apnea
- Pulmonary problems such as moderate or severe bronchial asthma
- Cardiovascular problems such as hypertension
- History of claustrophobia
- Presence of a pacemaker, defibrillator, surgically placed metallic object (e.g., hip replacement)or other implanted device
- Presence of an unremoved bullet or shrapnel in the body
- Presence of a prosthetic that is not removable
- Presence of a hearing aid needed for hearing
- Head girth exceeding that of the head coil used in the magnet
- Extensive metalwork on or in teeth, or irremovable false teeth or bridgework
- Epilepsy
- Chronic analgesic medication
- Excessive tattoos (due to local skin heating with tattoos containing ferromagnetic particles)
- History of surgery for which details are unavailable
- Allery due to study drugs
- History of drug abuse
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT00853333
Start Date
November 1 2008
End Date
January 1 2012
Last Update
June 26 2014
Active Locations (1)
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1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294