Status:
UNKNOWN
Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)
Lead Sponsor:
Medical Center Alkmaar
Collaborating Sponsors:
Leiden University Medical Center
University of Amsterdam
Conditions:
Chronic Obstructive Pulmonary Disease
Inflammation
Eligibility:
All Genders
41+ years
Phase:
PHASE4
Brief Summary
COPD is a progressive pulmonary disease that is characterized by an inflammatory process in the airways and the lungs which leads to progressive airway obstruction. The inflammation is associated with...
Detailed Description
Rationale: COPD is a disease characterized by chronic inflammation and irreversible airway obstruction. Chronic inflammation lead to degradation of extracellular matrix and hereby destruction of lung...
Eligibility Criteria
Inclusion
- GOLD II or III COPD (GOLD II: FEV1/FVC \< 70%; 50% \< FEV1 \< 80% predicted, GOLD III: FEV1/FVC \< 70%; 30% \< FEV1 \< 50% predicted ).
- Stable disease (no exacerbations in the last 3 months).
- Age \> 40 yrs.
- Written informed consent.
Exclusion
- Infections and/or use of antibiotics in the last month.
- Bacterial colonization of the airways, proven by sputum cultures or broncho-alveolar lavage (BAL).
- Allergy for tetracyclines or a history of substantial side-effects.
- Active respiratory diseases other than COPD (e.g. sarcoidosis, tuberculosis, lung cancer, bronchiectasis).
- Acute exacerbation of COPD as defined by Anthonisen et al. \[10\].
- Signs and/or symptoms of a current respiratory or non-respiratory infection.
- Use of oral or intravenous corticosteroids or other immunosuppressive drugs within the last month.
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2010
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00857038
Start Date
April 1 2009
End Date
January 1 2010
Last Update
March 6 2009
Active Locations (1)
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1
Medical Center Alkmaar
Alkmaar, North Holland, Netherlands, 1815JD