Status:
TERMINATED
Cytokines and the Risk of Infection in Liver Cirrhosis
Lead Sponsor:
Medical University of Graz
Conditions:
Liver Cirrhosis
Eligibility:
All Genders
18+ years
Brief Summary
The aim of this study is to test whether the oscillation of cytokine concentrations in serum is able to predict the development of infection in patients with liver cirrhosis.
Detailed Description
Patients with liver cirrhosis frequently develop bacterial, viral or fungal infections which are the main trigger for decompensation of cirrhosis and development of complications and thereby infection...
Eligibility Criteria
Inclusion
- Patients with clinical, radiological and/or histological evidence of liver cirrhosis
- Age above 18 (inclusive) at the time of screening
- Able and willing to give written informed consent and to comply with the requirements of the study
Exclusion
- Infection during the last 14 days before screening
- Gastrointestinal bleeding within the last 14 days before screening
- Antibiotic therapy at the time of screening (except prophylaxis of spontaneous bacterial peritonitis)
- Shock or cardiac failure requiring inotrope treatment at the time of screening
- Hepatic encephalopathy grade \>2
- Findings suggestive of organic nephropathy or a serum creatinine level of more than 2 mg/dl
- Human immunodeficiency virus infection at time of inclusion
- Use of immunomodulating agents within one month prior to screening (e.g. steroids)
- Any disease (e.g., advanced neoplasia) that could affect the short-term prognosis
- Any disease or condition which the investigator or treating physician feels would interfere with the trial or the safety of the subject
Key Trial Info
Start Date :
March 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00857181
Start Date
March 1 2009
End Date
March 1 2010
Last Update
March 5 2012
Active Locations (1)
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1
Medical University Graz
Graz, Styria, Austria, 8036