Status:
TERMINATED
The Efficacy of Oral Everolimus in Patients With Neovascular Age-related Macular Degeneration
Lead Sponsor:
Novartis Pharmaceuticals
Conditions:
Choroidal Neo-Vascular Age-onset Macular Degeneration
Age-related Macular Degeneration
Eligibility:
All Genders
50+ years
Phase:
PHASE2
Brief Summary
The study will assess the safety and efficacy of Everolimus (RAD001) alone or in combination with Lucentis in patients with neo-vascular age related macular degeneration (AMD)
Eligibility Criteria
Inclusion
- Patients with neovascular Age-Related Macular Degeneration (AMD)
- Best corrected visual acuity ( BCVA) of 20/40 or worse in study eye
- Patients with predominantly classic, minimally classic, or occult choroidal neovascularization in the macula of one eye (the study eye) who have had an inadequate response to VEGF inhibitors in the study eye. Inadequate response is defined as a gain of less than one line of visual acuity and persistent macular edema (central sub-fiel thickness ≥ 300 μm as measured by Optical Coherence Tomography (OCT) despite a minimum of 3 treatments with Lucentis or Avastin
Exclusion
- Any concurrent ocular condition in the study eye that may result in substantial change in vision during the study
- Uncontrolled medical conditions such as cancer, angina, diabetes, viral or fungal infections, impaired lung function, history of stroke
- Patients who have macular edema in the study eye that, in the judgment of the investigator, is unlikely to respond to treatment. Examples of features that may guide the investigator's judgment about unresponsiveness are large regions of geographic atrophy, retinal angiomatous proliferation, or large regions of sub-retinal fibrosis. The presence of one of these features excludes a patient only if the investigator judges the study eye to have irreversible macular edema.
- active bacterial, fungal or viral infections at the time of enrollment, e.g. hepatitis B or C infection. Patients with risk factors for hepatitis B should be tested for hepatitis B viral load and serological markers at screening (a positive HBV-DNA, HBsAg). Patients with risk factors for hepatitis C should be tested using HCVRNA-PCR at screening. A clinical history of hepatitis B or hepatitis C will exclude the patient from the study.
- Other protocol-defined inclusion/exclusion criteria may apply
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00857259
Start Date
February 1 2009
Last Update
August 19 2011
Active Locations (12)
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1
Retina-Vitreous Associates Medical Group
Beverly Hills, California, United States, 90211
2
Retinal Consultants Medical Group, Inc.
Sacramento, California, United States
3
Porter Adventist Hospital, Diagnostic Eye Laboratory
Denver, Colorado, United States, 80210
4
Discover Vision Center
Independence, Missouri, United States, 64055