Status:
COMPLETED
Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study B
Lead Sponsor:
Nemours Children's Clinic
Collaborating Sponsors:
Juvenile Diabetes Research Foundation
Conditions:
Diabetes Mellitus, Type 1
Eligibility:
All Genders
12-21 years
Phase:
NA
Brief Summary
Glutathione is normally present at high levels in the blood and plays an important role in the body's defense against oxidative stress, that is, against the damage caused to the body by several reacti...
Detailed Description
Forty adolescents with T1D will undergo a measurement of blood glutathione concentration and markers of oxidative stress (plasma protein-bound 3-nitrotyrosine, and urinary 8OH-2-dG, and F2-isoprostane...
Eligibility Criteria
Inclusion
- Type 1 diabetes, using usual criteria such as: glycosuria, hyperglycemia prior to treatment
- BMI \<25 kg/m2
- Age 12-21
- HbA1c\>7.5%
- No evidence of diabetic complications
- Written informed consent from parents or legal guardian, and assent from patient
Exclusion
- Presence of significant anemia (hemoglobin \<11g/dL)
- Presence of intercurrent illness such as infection
- Presence of chronic disease such as other endocrine deficiency, chronic respiratory or cardiac disease
- Chronic use of medication other than insulin
- Use of vitamin or mineral supplements within 2 weeks of study
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT00858273
Start Date
March 1 2008
End Date
August 1 2011
Last Update
May 17 2023
Active Locations (1)
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1
Nemours Children's Clinic
Jacksonville, Florida, United States, 32207