Status:
COMPLETED
Neurophysiology and Pharmacology of Cough Reflex Hypersensitivity
Lead Sponsor:
Jacky Smith
Conditions:
Chronic Cough
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
A cough lasting more than 2 months is known as a chronic cough, affecting 12-23% of the adult non-smoking population. Chronic cough has many associated complications including incontinence, muscular c...
Eligibility Criteria
Inclusion
- Healthy Volunteers:
- Over 18 years old
- Measurable cough reflex sensitivity
- No current or past history of chronic cough or chronic respiratory disease.
- No symptoms of gastro-oesophageal reflux disease, asthma or post-nasal drip.
- Chronic Cough Patients
- Over 18 years old
- Chronic persistent cough (\> 8 weeks) despite investigation and/or treatment trials for cough variant asthma/post nasal drip and gastro-oesophageal reflux disease.
- Normal CXR
- Normal lung function
- Measurable cough reflex sensitivity
Exclusion
- Recent Upper Respiratory Tract Infection (4 weeks)
- Pregnancy/breast feeding
- Current smokers or ex-smokers with \< 6 months abstinence or cumulative history of \> 10 packyears
- Diabetes Mellitus
- Opiate or ACE Inhibitor use.
- Any centrally acting medication which has the potential to alter cough reflex sensitivity.
- Significant and ongoing chronic respiratory, cardiovascular (in particular hypertension), gastro-intestinal, haematological (porphyria), neurological or psychiatric illness.
- Drug or alcohol abuse
- History of allergy or reaction to ketamine of other NMDA receptor antagonists.
Key Trial Info
Start Date :
February 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00858624
Start Date
February 1 2008
End Date
July 1 2009
Last Update
June 19 2013
Active Locations (1)
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1
University of Manchester, Education and Research Centre, Wythenshawe Hospital
Manchester, Manchester, United Kingdom, M23 9LT