Status:
COMPLETED
Immunologic Predisposition of HIV Patients to Develop Methicillin-Resistant Staphylococcus Aureus (MRSA) Colonization and Infection
Lead Sponsor:
Henry M. Jackson Foundation for the Advancement of Military Medicine
Collaborating Sponsors:
Infectious Diseases Clinical Research Program
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
HIV Infections
Staphylococcal Infections
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to investigate the role of T helper 17 cells (Th17) in the pathogenesis of MRSA infections.
Eligibility Criteria
Inclusion
- All participant inclusion criteria:
- Greater or equal to 18 years of age
- Willingness to undergo blood draw. Skin biopsy will be requested, but is optional
- AND-
- HIV-positive and MRSA-negative Group:
- Documented positive HIV test result
- Negative colonization swabs for S. aureus within 14 days of enrollment
- No evidence of skin/soft tissue infection
- HIV-positive and MRSA-Colonization Group:
- Documented positive HIV test result
- History of of colonization with MRSA w/in 14 days of study enrollment
- HIV-positive and MRSA Infection Group:
- Documented positive HIV test result
- Skin/soft tissue infection with a positive wound culture showing MRSA within 7 days of enrollment
- MRSA infection is not associated with an intravenous catheter or other nosocomial procedure
- HIV Negative groups:
- Same criteria used for the HIV-negative groups as listed above.
- No history of HIV infection.
- Willing to undergo an HIV blood test, which must have a negative result.
- Exclusion Criteria:
- Women with positive urine pregnancy test within 7 days of study enrollment
- Women who are within 6 months of being postpartum or who are currently breastfeeding
- Subjects unable or unwilling to complete questionnaires and blood draw.
Exclusion
Key Trial Info
Start Date :
March 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 26 2016
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT00859677
Start Date
March 1 2009
End Date
August 26 2016
Last Update
February 15 2023
Active Locations (2)
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1
Naval Medical Center San Diego
San Diego, California, United States, 92134
2
Walter Reed National Military Medical Center
Bethesda, Maryland, United States, 20889