Status:
COMPLETED
Respiratory and Autonomic Plasticity Following Intermittent Hypoxia
Lead Sponsor:
VA Office of Research and Development
Conditions:
Sleep Apnea Syndromes
Eligibility:
All Genders
20-40 years
Phase:
EARLY_PHASE1
Brief Summary
The prevalence of obstructive sleep apnea is high in the Veteran population. If not treated promptly, sleep apnea may result in daytime fatigue which may lead to increased prevalence of accidents whil...
Detailed Description
Approximately 8 % of the Veteran population in the United States suffers from sleep apnea. Consequences of untreated sleep apnea include increased daytime fatigue, hypertension and stroke. Thus, sleep...
Eligibility Criteria
Inclusion
- Characteristics of OSA subject population:
- Body mass index \< 30 kg/m2.
- 20 to 40 years old.
- Newly diagnosed never-treated mild to moderate sleep apnea (i.e. 50 \> apnea/hypopnea index \>10 events per hour - average nocturnal oxygen saturation \> 90%).
- Not pregnant.
- Free of any other known medical conditions.
- Not taking any medication.
- Non-smokers with normal lung function.
- Minimal alcohol consumption (i.e. no more than the equivalent of a glass of wine/day).
- Characteristics of control group population:
- Body mass index \< 30 kg/m2.
- 20 to 40 years old.
- Apnea/hypopnea index \< 5 events per hour.
- Not pregnant.
- Free of any known medical conditions.
- Not taking any medication.
- Non-smokers with normal lung function.
- Minimal alcohol consumption (i.e. no more than the equivalent of a glass of wine/day).
Exclusion
- Anything not in inclusion criteria.
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2013
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT00860743
Start Date
September 1 2009
End Date
September 1 2013
Last Update
November 1 2017
Active Locations (1)
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1
John D. Dingell VA Medical Center, Detroit
Detroit, Michigan, United States, 48201