Status:
COMPLETED
Comparison of Pitavastatin With Atorvastatin in Increasing High Density Lipoprotein - Cholesterol (HDL-C) and Adiponectin in Patients With Dyslipidemia and Coronary Artery Disease (CAD)
Lead Sponsor:
Kumamoto University
Conditions:
Hypercholesterolemia
Coronary Artery Disease
Eligibility:
All Genders
20-85 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare the effects of pitavastatin and atorvastatin on adiponectin percentage change in patients with hypercholesteremia comorbid stable CAD.
Detailed Description
The efficiency of lipid lowering therapy was already proven by the clinical trials of statins. According to these results, the target value of LDL-C is recommended under 100mg/dL in the Japan Atherosc...
Eligibility Criteria
Inclusion
- Patients with dyslipidemia as defined by any of the parameters:
- HDL-C \< 50 mg/dL
- LDL-C ≥ 140 mg/dL
- LDL-C ≥ 100 mg/dL and cholesterol-lowering treatment is necessary in accordance with the investigator's judgement
- Patients who passed three months or more after acute myocardial infarction
- Patients who passed one month or more after unstable angina
- Patients who passed one month or more after PCI
- Patients with written consent by their own volition after being provided sufficient explanation for the participation into this clinical trial
Exclusion
- Patients with any allergy to pitavastatin or atorvastatin
- Patients with familial hypercholesterolemia
- Patients receiving pitavastatin
- Patients with severe hypertension
- Patients with renal disorders or undergoing dialysis
- Patients with hepatobiliary disorders
- Patients with hepatobiliary disorders
- Patients with family history of hypothyroidism or muscular dystrophy
- Patients with history of drug-induced hepatic disorder
- Drug abuser or dipsomaniac
- Patients with cardiogenic shock.
- Patients who hopes for pregnancy during this study
- Contraindications, Relative Contraindications, Absolute Contraindications for Coadministration and Relative Contraindications for Coadministration for pitavastatin or atorvastatin
- Patients who are ineligible in the opinion of the investigator
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2013
Estimated Enrollment :
129 Patients enrolled
Trial Details
Trial ID
NCT00861861
Start Date
September 1 2008
End Date
October 1 2013
Last Update
October 14 2013
Active Locations (1)
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1
Kumamoto University Graduate School of Medical Sciences Department of Cardiocascular Medicine
Kumamoto, Kumamoto, Japan, 860-8556