Status:
UNKNOWN
The Effect of Rebamipide for Non-steroidal Anti-inflammatory Drugs (NSAID) - Induced Small-intestinal Injuries
Lead Sponsor:
Nagoya University
Conditions:
NSAIDs-induced Small-intestinal Injuries
Eligibility:
All Genders
20-85 years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate the efficacy of rebamipide for NSAID-induced small-intestinal injuries.
Eligibility Criteria
Inclusion
- Written informed consent
- 20 to 85 years of age
- RA, OA, or low back pain
- No change of drugs before 3 months
- Under 5 mg of corticosteroid use
- CRP \< 1mg/dl
- Small-intestinal mucosal injuries more than one
- Hemoglobin level is below normal range
Exclusion
- Known or suspected small-bowel disease, including Crohn's disease and seronegative arthritis
- Prostaglandins, metronidazole or salazosulfapyridine
- Can not swallow
- Eith pacemaker
- After gastrointestinal operation
- Serious concomitant cardiovascular, endocrine, gastrointestinal(including symptoms of ileus), neurologic, psychiatric, renal, or respiratory disease.
- Taking rebamipide before one week
- Any other conditions that the investigator feels would interfere with data interpretation or create under risk.
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2010
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00862628
Start Date
October 1 2009
End Date
October 1 2010
Last Update
September 21 2009
Active Locations (2)
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1
Department of Gastroenterology, Nagoya University Graduate School of Medicine
Nagoya, Aichi-ken, Japan, 466-8550
2
Department of Gastroenterology, Nagoya University Graduate School of Medicine
Nagoya, Aichi-ken, Japan, 466-8550