Status:
COMPLETED
D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
Lead Sponsor:
University of South Florida
Conditions:
Obsessive-compulsive Disorder
Eligibility:
All Genders
8-17 years
Phase:
PHASE2
Brief Summary
Cognitive-behavioral therapy (CBT) has proven efficacy for treatment of pediatric obsessive-compulsive disorder (OCD). Yet, CBT does not help all children and those who benefit often remain symptomati...
Detailed Description
Cognitive-behavioral therapy (CBT) has proven efficacy for treatment of pediatric obsessive-compulsive disorder (OCD). Yet, CBT does not help all children and those who benefit often remain symptomati...
Eligibility Criteria
Inclusion
- The child must receive a principal diagnosis of OCD at Baseline, based on DSM-IV criteria. This diagnosis will be derived from the Anxiety Disorder Interview Schedule for DSM-IV-Child Interview Schedule - Parent version (ADIS-IV-P), and must reflect a clinical severity rating of 4 or above
- CY-BOCS Total Score ≥ 16
- Be between the ages of 8 and 17 years
- Score ≥ 80 on the Peabody Picture Vocabulary Test-3rd Edition (Dunn \& Dunn, 1997)
- At least one parent available to accompany the child to all sessions;
- English speaking.
Exclusion
- Psychosis, pervasive developmental disorder, bipolar disorder, or current suicidal intent measured by the ADIS-IV-P and all available clinical information
- Principal diagnosis other than OCD
- Youth with mental rituals, incompleteness, or hoarding symptoms as E/RP exercises would be more difficult to conduct/monitor than those with overt rituals
- Unavailability of at least one caregiver to participate in the treatment
- Refusal of parent to accept random assignment to treatment condition
- A positive diagnosis in the caregiver of mental retardation, psychosis, clinically significant tics, or other psychiatric disorders or conditions that would limit their ability to understand E/RP (based on clinical interview)
- Weight less than 25.0 kg or greater than 80.0kg
- Epilepsy, renal insufficiency, and current or past history of alcohol abuse (DCS is contraindicated for such conditions)
- Pregnant or having unprotected sex \[in females\] as the effects of DCS on pregnant youth are unknown
- General poor physical health as determined by medical physical and laboratory tests.
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2009
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00864123
Start Date
January 1 2008
End Date
November 1 2009
Last Update
October 17 2012
Active Locations (1)
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1
University of South Florida
St. Petersburg, Florida, United States, 33701